Kousaku Ohno Selected Research

N-octyl-beta-valienamine

5/2007	Enzyme enhancement activity of N-octyl-beta-valienamine on beta-glucosidase mutants associated with Gaucher disease.
8/2004	N-octyl-beta-valienamine up-regulates activity of F213I mutant beta-glucosidase in cultured cells: a potential chemical chaperone therapy for Gaucher disease.
12/2003	Chemical chaperone therapy for brain pathology in G(M1)-gangliosidosis.

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Kousaku Ohno Research Topics

Disease

19	Type C Niemann-Pick Disease (Niemann Pick Disease, Type C) 01/2021 - 09/2002
14	Gaucher Disease (Gaucher's Disease) 05/2021 - 08/2004
6	Seizures (Absence Seizure) 05/2015 - 12/2002
6	Tuberous Sclerosis (Bourneville's Disease) 12/2011 - 06/2002
5	Neurologic Manifestations (Neurological Manifestations) 05/2021 - 09/2007
5	Thrombosis (Thrombus) 01/2018 - 12/2015
5	Sphingolipidoses (Sphingolipidosis) 04/2013 - 08/2004
4	Epilepsy (Aura) 03/2016 - 06/2002
3	Lysosomal Storage Diseases (Lysosomal Storage Disease) 03/2019 - 12/2003
3	Brain Diseases (Brain Disorder) 05/2015 - 11/2006
3	GM1 Gangliosidosis (Gangliosidosis GM1) 03/2013 - 12/2003
3	Infantile Spasms (West Syndrome) 02/2009 - 12/2007
3	Neoplasms (Cancer) 09/2007 - 06/2002
3	Status Epilepticus (Complex Partial Status Epilepticus) 04/2007 - 12/2002
2	Disease Progression 08/2018 - 11/2006
2	Narcolepsy 08/2018 - 01/2008
2	Cerebral Infarction 10/2016 - 12/2015
2	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 10/2016 - 12/2015
2	Ischemic Stroke 10/2016 - 12/2015
2	Infarction (Infarctions) 10/2016 - 12/2015
2	Ischemia 04/2016 - 03/2003
2	Neurodegenerative Diseases (Neurodegenerative Disease) 03/2016 - 08/2011
2	Pain (Aches) 01/2016 - 11/2006
2	Fabry Disease (Fabry's Disease) 09/2015 - 07/2014
2	Hypothermia 04/2014 - 11/2006
2	Mucopolysaccharidosis IV (Morquio Syndrome) 03/2013 - 12/2003
2	Glycogen Storage Disease Type II (Pompe's Disease) 11/2012 - 10/2003
2	Focal Cortical Dysplasia 12/2011 - 08/2008
2	Malformations of Cortical Development 12/2011 - 08/2008
2	Hypoglycemia (Reactive Hypoglycemia) 10/2009 - 09/2007
2	Hamartoma 09/2007 - 04/2004
1	Ototoxicity 01/2021
1	Hepatomegaly 03/2019
1	Parkinson Disease (Parkinson's Disease) 01/2019
1	Splenomegaly 08/2018
1	Thrombocytopenia (Thrombopenia) 01/2018
1	Lesch-Nyhan Syndrome (Choreoathetosis Self Mutilation Hyperuricemia Syndrome) 01/2017
1	Intracranial Thrombosis (Cerebral Thrombosis) 10/2016
1	Myoclonus (Nocturnal Myoclonus) 03/2016
1	Peripheral Nervous System Diseases (PNS Diseases) 01/2016
1	Thrombotic Stroke 12/2015
1	Hyperplasia 12/2015
1	Fibrosis (Cirrhosis) 12/2015
1	Carotid Artery Injuries 12/2015
1	Niemann-Pick Diseases (Niemann Pick Disease) 09/2015
1	Digestive System Diseases 09/2015
1	Meningitis 05/2015
1	Bacterial Infections (Bacterial Infection) 05/2015
1	Sepsis (Septicemia) 05/2015

Drug/Important Bio-Agent (IBA)

9	AcidsIBA 04/2014 - 10/2003
8	CholesterolIBA 01/2021 - 06/2004
8	Glucosylceramidase (Glucocerebrosidase)IBA 03/2016 - 12/2008
7	LipidsIBA 10/2019 - 06/2004
5	Proteins (Proteins, Gene)FDA Link 10/2019 - 03/2003
5	CyclodextrinsIBA 01/2017 - 01/2013
5	GlucosidasesIBA 04/2014 - 11/2010
5	trans-sodium crocetinate (crocetin)IBA 08/2008 - 06/2002
4	Ambroxol (Mucosolvan)IBA 05/2021 - 04/2013
4	Prasugrel Hydrochloride FDA Link 10/2016 - 12/2015
4	EnzymesIBA 03/2016 - 05/2007
4	GalactosidasesIBA 09/2015 - 08/2011
3	ferric chlorideIBA 01/2018 - 12/2015
3	Pharmaceutical PreparationsIBA 01/2016 - 04/2013
3	Adrenocorticotropic Hormone (ACTH)FDA Link 02/2009 - 12/2007
3	N-octyl-beta-valienamineIBA 05/2007 - 12/2003
2	Anticonvulsants (Antiepileptic Drugs)IBA 03/2016 - 05/2015
2	Fibrinolytic Agents (Antithrombotic Agents)IBA 01/2016 - 12/2015
2	Messenger RNA (mRNA)IBA 12/2015 - 06/2004
2	GlycosidesIBA 01/2015 - 08/2012
2	migalastatIBA 07/2014 - 03/2013
2	Glucosylceramides (Glucocerebrosides)IBA 04/2014 - 12/2008
2	Valproic Acid (Depakote)FDA LinkGeneric 04/2014 - 05/2006
2	alpha-Glucosidases (Acid Maltase)IBA 11/2012 - 10/2003
2	Biological ProductsIBA 12/2011 - 08/2008
2	Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)IBA 12/2011 - 08/2008
2	NeuropeptidesIBA 01/2008 - 05/2006
2	Tuberous Sclerosis Complex 1 ProteinIBA 09/2007 - 05/2007
2	beta-GlucosidaseIBA 05/2007 - 08/2004
2	CytokinesIBA 02/2007 - 11/2006
2	beta-N-AcetylhexosaminidasesIBA 01/2003 - 01/2002
1	alpha-SynucleinIBA 01/2019
1	Modafinil (Provigil)FDA Link 08/2018
1	Filipin (Filipin III)IBA 08/2018
1	P-SelectinIBA 01/2018
1	Adenosine Diphosphate (ADP)IBA 01/2018
1	CollagenIBA 01/2018
1	S-Adenosylmethionine (Ademetionine)IBA 01/2017
1	R-138727IBA 10/2016
1	Purinergic P2Y Receptor AntagonistsIBA 04/2016
1	Carrier Proteins (Binding Protein)IBA 03/2016
1	Voltage-Gated Sodium ChannelsIBA 01/2016
1	Platelet Aggregation Inhibitors (Antiplatelet Drugs)IBA 12/2015
1	thienopyridineIBA 12/2015
1	SolutionsIBA 12/2015
1	Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)IBA 12/2015
1	Oxidoreductases (Dehydrogenase)IBA 09/2015
1	C-Reactive ProteinIBA 05/2015
1	Blood Glucose (Blood Sugar)IBA 05/2015
1	Aspartate Aminotransferases (Aspartate Transaminase)IBA 05/2015

Therapy/Procedure

11	Therapeutics 01/2019 - 12/2003